Mechanism of cell slippage during mitotic arrest a Rapid degradation Biology Diagrams
Mechanism of cell slippage during mitotic arrest a Rapid degradation Biology Diagrams In this cell line, the ablation of the 14-3-3-ฯ locus also abolishes the G2 arrest and causes mitotic catastrophe linked to the premature entry of cyclin B/Cdk1 into the nucleus (Chan et al., 1999).
For example, increased expression of mitotic arrest deficient 2 (Mad2)-interacting protein p31 comet causes cellular senescence, which is accompanied by mitotic catastrophe . Such combination of drugs causes prolonged arrest of the cell cycle in the G2/M phase, accumulation of micronuclei, and chromosomal aberrations indicative of mitotic
DNA damage associated with mitosis and cytokinesis failure Biology Diagrams
Prolonged mitotic arrest with the same drugs causes apoptosis during mitotic arrest in apoptosis-sensitive cell lines; in less sensitive lines, cells undergo slippage without division into tetraploid G1, which may be followed by p53-dependent arrest, apoptosis, or another round of mitosis (Rieder and Maiato, 2004; Gascoigne and Taylor, 2008
Mitotic arrest is defined as the difference between mitotic exit and mitotic entry. Central panel: barplots with the percentages of the different classes of Clb2 behavior in wild-type or GAL1-Mad2 cells arrested indefinitely in nocodazole. For the definition of the cell classes see S2A Fig. Right panel: cumulative distribution of APC/C Suppression of mitotic telomere damage by enhanced expression of TRF2, or the inhibition of either caspase-3/7 or DNA-PK during mitotic arrest, promotes subsequent cell survival.
Mitotic arrest and cell fate: why and how mitotic inhibition of ... Biology Diagrams
While recovery from transient drug treatment and mitotic progression with extra centrosomes is associated with some degree of mitotic arrest , possibly predisposing cells to telomeric DNA damage as described above, premature satisfaction or inhibition of the SAC also causes lagging chromosomes and micronucleus formation without detectable Mitotic arrest induced by antimitotic drugs can cause apoptosis or p53-dependent cell cycle arrest. It can also cause DNA damage, but the relationship between these events has been unclear. Live, single-cell imaging in human cancer cells responding to an antimitotic kinesin-5 inhibitor and additiona โฆ Microtubule inhibitors such as paclitaxel, vincristine and nocodazole cause mitotic arrest. Cell fate determination during mitotic arrest may seem like a puzzle. If a cell cannot exit mitosis, 1it undergoes apoptosis.-4 On the other hand, apoptosis may require mitotic 2,5,6exit. Apoptosis is often p53-independent but can be p53-dependent.1,6-12
